Bionetic
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Bionetic
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Bionetic
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Trimethylglycine (TMG, betaine anhydrous) donates methyl groups through betaine-homocysteine methyltransferase (BHMT) — the liver-specific enzyme that converts homocysteine to methionine independently of the folate/B12-dependent MTHFR pathway. This makes TMG a critical redundant methylation safeguard, particularly important in individuals with MTHFR polymorphisms or inadequate folate status. As an osmolyte, TMG protects cells from hyperosmotic stress by accumulating in the cytoplasm as a compatible solute. In sports performance, controlled trials at 2.5 g/day demonstrate significant increases in peak power output (8.6%) and mean power output (6.4%), attributed to creatine synthesis support and intracellular water retention enhancing force production.
Key Capabilities
Supplement Facts
| Per serving | |
|---|---|
| Trimethylglycine (TMG) (as Betaine anhydrous) | 1000 mg |
Other ingredients: Capsule shell: gelatin; anti-caking agent: magnesium salts of fatty acids; bulking agent: microcrystalline cellulose.
Key Features
BHMT pathway methyl donor — lowers homocysteine independently of MTHFR
Critical methylation safeguard for MTHFR polymorphism carriers
Osmolyte function — protects cells from hyperosmotic dehydration stress
Clinically shown to increase peak power by 8.6% and mean power by 6.4%
Supports creatine synthesis by donating methyl group to guanidinoacetate
Supports liver betaine-dependent methionine recycling and lipid metabolism
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