Licorice Root Extract + DGL

Glycyrrhiza glabra root contains over 300 identified phytochemicals, with glycyrrhizin and its aglycone glycyrrhetinic acid being primary bioactives. However, glycyrrhizin inhibits 11β-hydroxysteroid dehydrogenase, causing pseudohyperaldosteronism with chronic use. The deglycyrrhizinated (DGL) form retains the mucilaginous polysaccharides, flavonoids (liquiritigenin, isoliquiritigenin), and saponins responsible for gastroprotective effects — stimulating mucin secretion, increasing prostaglandin E2-mediated mucosal blood flow, and inhibiting Helicobacter pylori adhesion to gastric epithelium — while eliminating the mineralocorticoid-like risk. Multiple controlled trials confirm DGL reduces upper GI discomfort, gastric ulcer healing time, and dyspepsia symptoms as effectively as antacids without rebound acid hypersecretion.