Choline + Inositol

Choline and inositol are two structurally related essential nutrients that together underpin phospholipid membrane biosynthesis and neurochemical signalling. Choline is the direct precursor to phosphatidylcholine — the predominant phospholipid in neuronal cell membranes — and to acetylcholine, the neurotransmitter governing memory encoding, cognitive focus, and parasympathetic nervous system function. Inositol (myo-inositol) serves as the backbone of phosphatidylinositol phosphates, the lipid second messengers mediating serotonin receptor, dopamine receptor, and insulin receptor intracellular signalling. Clinical trials in OCD and depression demonstrate that 12–18 g inositol/day produces significant improvements comparable to SSRIs, attributed to its resensitisation of serotonergic receptor second-messenger cascades.