Neuromax P-5-P

Pyridoxal-5-phosphate (P-5-P) is the biologically active coenzyme form of vitamin B6, required by over 100 enzymes in amino acid metabolism — including the critical decarboxylases that synthesise serotonin from 5-HTP, dopamine from DOPA, GABA from glutamate, and histamine from histidine. Unlike pyridoxine HCl (the common supplemental form), P-5-P requires no hepatic phosphorylation and is immediately bioavailable to all tissues including the brain. P-5-P is also essential for the transsulfuration pathway converting homocysteine to cystathionine (with folate and B12), making it a critical cardiovascular and neurological protectant. Neuromax P-5-P addresses the widespread inadequacy of pyridoxine-to-P5P conversion efficiency, particularly in older adults and those with genetic variants in the PNPO gene.