Bionetic
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Bionetic
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Bionetic
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NAD+ (nicotinamide adenine dinucleotide) is the central currency of cellular metabolism, declining by 50% between ages 20 and 60 in human tissues. As the primary electron carrier in mitochondrial oxidative phosphorylation, NAD+ is rate-limiting for ATP production; as a cosubstrate for the sirtuin family of deacylases (SIRT1–SIRT7) and PARP1 DNA repair enzyme, it is rate-limiting for cellular defence against genomic instability. NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) supplementation raises intracellular NAD+ more efficiently than niacin by bypassing the rate-limiting NAMPT enzyme. Landmark animal studies demonstrate NAD+ repletion reverses vascular ageing, muscle atrophy, and cognitive decline, with human trials confirming NAD+ biomarker elevation and metabolic improvement.
Key Capabilities
Supplement Facts
| Per serving | % NRV | |
|---|---|---|
| Nicotinamide riboside chloride | 300 mg | 1875% |
% NRV = % Nutrient Reference Value. A dash (—) indicates no reference value has been established.
Other ingredients: Capsule shell: gelatin; anti-caking agent: magnesium salts of fatty acids; bulking agent: microcrystalline cellulose.
Key Features
Restores NAD+ levels that decline 50% between ages 20–60
Rate-limiting substrate for mitochondrial ATP production (Complex I, II)
Activates SIRT1–SIRT7 sirtuins — longevity-associated deacylases
PARP1 cosubstrate for DNA damage repair and genomic stability
Clinical trials confirm NAD+ biomarker elevation and metabolic improvement
Bypasses NAMPT rate-limiting enzyme via NMN/NR pathway
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